Symbiosis Centre for Stem Cell Research (SCSCR)

Symbiosis Centre for Stem Cell Research (SCSCR) was established as a new initiative of Symbiosis International (Deemed University) on 29th July 2016. SCSCR is located at the hill base campus within Symbiosis School of Biological Sciences (SSBS), under the Faculty of Health Sciences (FoHS). The centre is a unique research centre in Pune that will perform research exclusively on stem cells.

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Head’s message

Welcome to Symbiosis Centre for Stem Cell Research (SCSCR) at Symbiosis International (Deemed University). SCSCR is strategically located in Symbiosis School of Biological Sciences (SSBS), providing an ideal ecosystem for the interaction of SCSCR faculty with the faculty members of SSBS. Most importantly, the location of SCSCR at the hill base campus, opposite the multi-specialty Symbiosis University Hospital & Research Centre (SUHRC), helps in bridging the gap between laboratory research and clinical practices.

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News

Ms. Dharitree Samal won 1st prize for her poster presentation at "Intra and Inter Cellular Regulatory Systems" conference hosted by University of Hyderabad between 18th -21st November 2024.

Dr Ruchi Mishra Tiwari won first prize for the poetry competition held at “Symbiosis Centre for Emotional Wellbeing (SCEW)” on the occasion of “World Mental Health Day” 10th October 2024. The theme was “Mental Health at Work".

Dr. Ruchi Mishra Tiwari, Assistant Professor at SCSCR, was invited as a Keynote Speaker at a five-day workshop/FDP at National Institute of Technology (NIT) Rourkela on 23rd August, 2024.

Team members

SCSCR members

Infrastructure

Projects

  1. Molecular Analyses of extra-cellular vesicles isolated from bone marrow derived mesenchymal stromal cells treated with specific signalling modifiers and assessment of their effects on the fate of hematopoietic stem cells- Funded by Department of Biotechnology (2018-2021, 47.6 lakhs). PI – Dr. Anuradha Vaidya, Co-PI: Dr. Lalita Limaye, Dr. Srikanth Rapole and Dr. Vaijayanti Kale

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Research

  • 1. Experimental Hematology
  • I) Microenvironment-mediated regulation of Hematopoietic Stem Cells:
  • (A) Priming of MSCs to boost their hematopoiesis-supportive ability

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Collaborators

Funding

Publications

2025

90. Kale V. Priming human bone marrow-derived mesenchymal stromal cells with signaling modifiers boosts their functionality: Potential application in regenerative therapies. Int J Biochem Cell Biol. 2025 Jan 7:106734. doi: 10.1016/j.biocel.2025.106734. Epub ahead of print. PMID: 39788281.

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2024

88. Dixit T, Vaidya A, Ravindran S. Therapeutic potential of antibody-drug conjugates possessing bifunctional anti-inflammatory action in the pathogenies of rheumatoid arthritis. Arthritis Res Ther. 2024 Dec 19;26(1):216. doi: 10.1186/s13075-024-03452-0. PMID: 39695738; PMCID: PMC11656801.

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2023

75. Pendse S, Chavan S,Kale V, Vaidya A. A comprehensive analysis of cell-autonomous and non-cell-autonomous regulation of myeloid leukemic cells: The prospect of developing novel niche-targeting therapies. Cell Biol Int. 2023 Aug 9. doi: 10.1002/cbin.12078. Epub ahead of print. PMID: 37554060.

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2022

66. Pallavi Budgude, Prajakta Teli, Anuradha Vaidya and Vaijayanti Kale (2022) The Role of Autophagy in the Regulation of Hematopoietic Stem Cells. In Autophagy in Stem Cell Maintenance and Differentiation. Series: Stem Cell Biology and Regenerative Medicine. Editors: Bhupendra V. Shravage · Kursad Turksen. ISBN: 978-3-031-17361-5, ISBN 978-3-031-17362-2 (eBook) https://doi.org/10.1007/978-3-031-17362-2_5. Book Chapter.

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2021

51. Das M, Kale V. Involvement of Extracellular vesicles in aging process and their beneficial effects in alleviating aging-associated symptoms. Accepted in Cell Biology International, 2021.

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2020

33. Das, M., Kale, V. Extracellular vesicles: Mediators of embryo-maternal crosstalk during pregnancy and a new weapon to fight against infertility. (2020) Eur J Cell Biol 99 (8), art. no. 151125, . https://doi.org/10.1016/j.ejcb.2020.151125

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2019

19. Kale, V.P. Application of "primed" Mesenchymal Stromal Cells in Hematopoietic Stem Cell Transplantation: Current Status and Future Prospects. (2019) Stem Cell Dev 28 (22), pp. 1473-1479. https://doi.org/10.1089/scd.2019.0149

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2018

4. Vaidya, A., Kale, V., Poonawala, M., Ghode, S. Mesenchymal stromal cells enhance the hematopoietic stem cell-supportive activity of resveratrol. (2018) Regen Med 13 (4), pp. 409-425. https://doi.org/10.2217/rme-2017-0143

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Multimedia

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